Drug interactions
Atorvastatin + Pretomanid
Severity: Moderate
Atorvastatin and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid-containing regimen is associated with hepatotoxicity, and atorvastatin can also raise liver enzymes. Combining them may add to liver injury risk, although a direct interaction is not established.
What this interaction means in plain words
Atorvastatin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity; no established pharmacokinetic mechanism.
What to do
Monitor liver enzymes regularly during therapy and consider holding atorvastatin if transaminases rise or hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Atorvastatin with Pretomanid?
MediHelp rates the interaction as moderate. Atorvastatin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The pretomanid-containing regimen is associated with hepatotoxicity, and atorvastatin can also raise liver enzymes. Combining them may add to liver injury risk, although a direct interaction is not established.
How serious is the interaction between Atorvastatin and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly during therapy and consider holding atorvastatin if transaminases rise or hepatotoxicity develops.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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