Drug interactions
Atorvastatin + Ranolazine
Severity: Moderate
Atorvastatin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine can modestly increase atorvastatin exposure, which may raise the risk of statin-related muscle toxicity. The effect is generally small but relevant at higher statin doses.
What this interaction means in plain words
Atorvastatin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein and possibly OATP1B1 by ranolazine reduces atorvastatin clearance.
What to do
Monitor for myalgia, weakness or dark urine, and use the lowest effective atorvastatin dose; check CK if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Ranolazine?
MediHelp rates the interaction as moderate. Atorvastatin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine can modestly increase atorvastatin exposure, which may raise the risk of statin-related muscle toxicity. The effect is generally small but relevant at higher statin doses.
How serious is the interaction between Atorvastatin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia, weakness or dark urine, and use the lowest effective atorvastatin dose; check CK if symptoms arise.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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