Drug interactions
Atorvastatin + Repotrectinib
Severity: Minor
Atorvastatin and Repotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is only a weak P-gp inhibitor, so an increase in repotrectinib exposure is unlikely to be clinically important. Repotrectinib, a CYP3A4 inducer, is more likely to lower atorvastatin levels.
What this interaction means in plain words
Atorvastatin and Repotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Repotrectinib belongs to Oncology.
Why it happens
Theoretical P-gp inhibition by atorvastatin; the reverse effect via CYP3A4 induction by repotrectinib is more plausible.
What to do
Monitor for repotrectinib adverse effects and check lipid response to atorvastatin; adjust the statin dose if efficacy is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Atorvastatin with Repotrectinib?
MediHelp rates the interaction as minor. Atorvastatin and Repotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is only a weak P-gp inhibitor, so an increase in repotrectinib exposure is unlikely to be clinically important. Repotrectinib, a CYP3A4 inducer, is more likely to lower atorvastatin levels.
How serious is the interaction between Atorvastatin and Repotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for repotrectinib adverse effects and check lipid response to atorvastatin; adjust the statin dose if efficacy is reduced.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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