Drug interactions
Atorvastatin + Resmetirom
Severity: Moderate
Atorvastatin and Resmetirom: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Resmetirom raises atorvastatin exposure through hepatic transporter inhibition, increasing the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Atorvastatin and Resmetirom can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Resmetirom belongs to Gastrointestinal Tract.
Why it happens
Resmetirom inhibits OATP1B1/1B3-mediated hepatic uptake of atorvastatin.
What to do
Limit the atorvastatin dose to 40 mg daily and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Resmetirom
- Gemfibrozil + Resmetirom Major
- Clopidogrel + Resmetirom Moderate
- Pravastatin + Resmetirom Moderate
- Resmetirom + Rosuvastatin Moderate
- Resmetirom + Simvastatin Moderate
- Hydrochlorothiazide-irbesartan + Resmetirom Minor
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Frequently asked questions
Can I take Atorvastatin with Resmetirom?
MediHelp rates the interaction as moderate. Atorvastatin and Resmetirom can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Resmetirom raises atorvastatin exposure through hepatic transporter inhibition, increasing the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Atorvastatin and Resmetirom?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the atorvastatin dose to 40 mg daily and monitor for muscle symptoms.
What other medicines interact with Resmetirom?
MediHelp also lists interactions of Resmetirom with, for example, Gemfibrozil, Clopidogrel, Pravastatin. The full list is on the Resmetirom page.
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