Drug interactions
Resmetirom + Rosuvastatin
Severity: Moderate
Resmetirom and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Resmetirom inhibits OATP1B1/1B3 transporters and raises rosuvastatin exposure, which increases the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Resmetirom and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Resmetirom belongs to Gastrointestinal Tract; Rosuvastatin belongs to Cardiovascular.
Why it happens
Resmetirom inhibits hepatic OATP1B1/1B3 uptake of rosuvastatin, increasing systemic exposure.
What to do
Limit the rosuvastatin dose to 20 mg daily and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Resmetirom
- Gemfibrozil + Resmetirom Major
- Atorvastatin + Resmetirom Moderate
- Clopidogrel + Resmetirom Moderate
- Pravastatin + Resmetirom Moderate
- Resmetirom + Simvastatin Moderate
- Hydrochlorothiazide-irbesartan + Resmetirom Minor
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Resmetirom with Rosuvastatin?
MediHelp rates the interaction as moderate. Resmetirom and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Resmetirom inhibits OATP1B1/1B3 transporters and raises rosuvastatin exposure, which increases the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Resmetirom and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the rosuvastatin dose to 20 mg daily and monitor for muscle symptoms.
What other medicines interact with Resmetirom?
MediHelp also lists interactions of Resmetirom with, for example, Gemfibrozil, Atorvastatin, Clopidogrel. The full list is on the Resmetirom page.
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