Drug interactions
Clopidogrel + Resmetirom
Severity: Moderate
Clopidogrel and Resmetirom: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel, via its acyl-glucuronide metabolite, inhibits CYP2C8 and raises resmetirom exposure. Higher resmetirom levels may increase adverse effects such as diarrhea, nausea and liver effects.
What this interaction means in plain words
Clopidogrel and Resmetirom can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Resmetirom belongs to Gastrointestinal Tract.
Why it happens
Clopidogrel's glucuronide metabolite inhibits CYP2C8-mediated resmetirom metabolism.
What to do
Reduce the resmetirom dose as stated in its labeling when used with moderate CYP2C8 inhibitors, and monitor for tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Resmetirom
- Gemfibrozil + Resmetirom Major
- Atorvastatin + Resmetirom Moderate
- Pravastatin + Resmetirom Moderate
- Resmetirom + Rosuvastatin Moderate
- Resmetirom + Simvastatin Moderate
- Hydrochlorothiazide-irbesartan + Resmetirom Minor
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Resmetirom?
MediHelp rates the interaction as moderate. Clopidogrel and Resmetirom can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel, via its acyl-glucuronide metabolite, inhibits CYP2C8 and raises resmetirom exposure. Higher resmetirom levels may increase adverse effects such as diarrhea, nausea and liver effects.
How serious is the interaction between Clopidogrel and Resmetirom?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the resmetirom dose as stated in its labeling when used with moderate CYP2C8 inhibitors, and monitor for tolerability.
What other medicines interact with Resmetirom?
MediHelp also lists interactions of Resmetirom with, for example, Gemfibrozil, Atorvastatin, Pravastatin. The full list is on the Resmetirom page.
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