Drug interactions
Resmetirom + Simvastatin
Severity: Moderate
Resmetirom and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Resmetirom raises simvastatin exposure through transporter inhibition, increasing the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Resmetirom and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Resmetirom belongs to Gastrointestinal Tract; Simvastatin belongs to Cardiovascular.
Why it happens
Resmetirom inhibits OATP1B1/1B3-mediated hepatic uptake of simvastatin, increasing systemic exposure.
What to do
Limit the simvastatin dose to 20 mg daily and monitor for muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Resmetirom
- Gemfibrozil + Resmetirom Major
- Atorvastatin + Resmetirom Moderate
- Clopidogrel + Resmetirom Moderate
- Pravastatin + Resmetirom Moderate
- Resmetirom + Rosuvastatin Moderate
- Hydrochlorothiazide-irbesartan + Resmetirom Minor
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Resmetirom with Simvastatin?
MediHelp rates the interaction as moderate. Resmetirom and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Resmetirom raises simvastatin exposure through transporter inhibition, increasing the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Resmetirom and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the simvastatin dose to 20 mg daily and monitor for muscle pain or weakness.
What other medicines interact with Resmetirom?
MediHelp also lists interactions of Resmetirom with, for example, Gemfibrozil, Atorvastatin, Clopidogrel. The full list is on the Resmetirom page.
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