Drug interactions
Atorvastatin + Risperidone
Severity: Minor
Atorvastatin and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is a P-glycoprotein substrate and atorvastatin is only a weak inhibitor of this transporter. No clinically important change in risperidone exposure is expected.
What this interaction means in plain words
Atorvastatin and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Possible weak P-glycoprotein inhibition by atorvastatin.
What to do
No dose adjustment is required. Monitor clinical response to risperidone as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Atorvastatin with Risperidone?
MediHelp rates the interaction as minor. Atorvastatin and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone is a P-glycoprotein substrate and atorvastatin is only a weak inhibitor of this transporter. No clinically important change in risperidone exposure is expected.
How serious is the interaction between Atorvastatin and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor clinical response to risperidone as usual.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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