Drug interactions
Atorvastatin + Stiripentol
Severity: Moderate
Atorvastatin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so atorvastatin exposure may change unpredictably. Increased exposure raises myopathy risk, while induction may reduce efficacy.
What this interaction means in plain words
Atorvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol alters CYP3A4 activity (inhibition and induction) and inhibits P-glycoprotein efflux.
What to do
Monitor for muscle symptoms and lipid response, adjusting the atorvastatin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Atorvastatin with Stiripentol?
MediHelp rates the interaction as moderate. Atorvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so atorvastatin exposure may change unpredictably. Increased exposure raises myopathy risk, while induction may reduce efficacy.
How serious is the interaction between Atorvastatin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and lipid response, adjusting the atorvastatin dose accordingly.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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