Drug interactions
Atropine + Ephedrine
Severity: Moderate
Atropine and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine may add to the pressor and heart rate effects of ephedrine, resulting in higher blood pressure and tachycardia.
What this interaction means in plain words
Atropine and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Ephedrine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: vagal blockade by atropine with sympathomimetic stimulation by ephedrine.
What to do
Monitor blood pressure and heart rate and reduce ephedrine doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Ephedrine?
MediHelp rates the interaction as moderate. Atropine and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine may add to the pressor and heart rate effects of ephedrine, resulting in higher blood pressure and tachycardia.
How serious is the interaction between Atropine and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce ephedrine doses as needed.
What other medicines interact with Ephedrine?
MediHelp also lists interactions of Ephedrine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Ephedrine page.
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