Drug interactions
Atropine + Fluphenazine
Severity: Moderate
Atropine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has anticholinergic properties that add to atropine's effects, raising the risk of dry mouth, urinary retention, constipation, tachycardia and confusion. Anticholinergics may also reduce the absorption and antipsychotic effect of oral phenothiazines.
What this interaction means in plain words
Atropine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, with possible reduced GI absorption of oral fluphenazine.
What to do
Monitor for anticholinergic toxicity and for loss of antipsychotic response, particularly in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Fluphenazine?
MediHelp rates the interaction as moderate. Atropine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has anticholinergic properties that add to atropine's effects, raising the risk of dry mouth, urinary retention, constipation, tachycardia and confusion. Anticholinergics may also reduce the absorption and antipsychotic effect of oral phenothiazines.
How serious is the interaction between Atropine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and for loss of antipsychotic response, particularly in elderly patients.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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