Drug interactions
Atropine + Haloperidol
Severity: Moderate
Atropine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has some anticholinergic activity, and adding atropine increases anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia, confusion and blurred vision. In older patients this may cause delirium or worsen cognition. Anticholinergics may also reduce the antipsychotic effect in some cases.
What this interaction means in plain words
Atropine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity, especially in elderly patients and those with glaucoma, urinary retention or ileus. Use the lowest effective atropine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Haloperidol?
MediHelp rates the interaction as moderate. Atropine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has some anticholinergic activity, and adding atropine increases anticholinergic effects such as dry mouth, constipation, urinary retention, tachycardia, confusion and blurred vision. In older patients this may cause delirium or worsen cognition. Anticholinergics may also reduce the antipsychotic effect in some cases.
How serious is the interaction between Atropine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in elderly patients and those with glaucoma, urinary retention or ileus. Use the lowest effective atropine dose.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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