Drug interactions
Atropine + Ipratropium
Severity: Minor
Atropine and Ipratropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antimuscarinic agents, so systemic atropine may add to the anticholinergic effects of ipratropium, such as dry mouth, urinary retention, tachycardia and blurred vision. Because inhaled ipratropium is poorly absorbed, the additive effect is usually small, but it can matter with high doses or in susceptible patients.
What this interaction means in plain words
Atropine and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atropine belongs to Miscellaneous; Ipratropium belongs to Respiratory.
Why it happens
Additive blockade of muscarinic acetylcholine receptors.
What to do
Monitor for anticholinergic effects such as urinary retention, tachycardia and dry mouth when atropine is given systemically. Avoid combining in patients with narrow-angle glaucoma or urinary outflow obstruction unless closely monitored.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Ipratropium?
MediHelp rates the interaction as minor. Atropine and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are antimuscarinic agents, so systemic atropine may add to the anticholinergic effects of ipratropium, such as dry mouth, urinary retention, tachycardia and blurred vision. Because inhaled ipratropium is poorly absorbed, the additive effect is usually small, but it can matter with high doses or in susceptible patients.
How serious is the interaction between Atropine and Ipratropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, tachycardia and dry mouth when atropine is given systemically. Avoid combining in patients with narrow-angle glaucoma or urinary outflow obstruction unless closely monitored.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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