Drug interactions
Atropine + Macimorelin
Severity: Moderate
Atropine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin is used to diagnose growth hormone deficiency, and drugs that change growth hormone release can distort the result. The labeling for macimorelin lists anticholinergics as agents that may blunt the response, which could lead to a false-positive diagnosis.
What this interaction means in plain words
Atropine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Macimorelin belongs to Endocrine.
Why it happens
Pharmacodynamic interference with growth hormone release; the exact mechanism is not well established.
What to do
Hold atropine before macimorelin testing for an adequate washout if clinically feasible. Interpret the test with caution if it cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Other interactions of Macimorelin
Frequently asked questions
Can I take Atropine with Macimorelin?
MediHelp rates the interaction as moderate. Atropine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin is used to diagnose growth hormone deficiency, and drugs that change growth hormone release can distort the result. The labeling for macimorelin lists anticholinergics as agents that may blunt the response, which could lead to a false-positive diagnosis.
How serious is the interaction between Atropine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold atropine before macimorelin testing for an adequate washout if clinically feasible. Interpret the test with caution if it cannot be stopped.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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