Drug interactions
Atropine + Perphenazine
Severity: Moderate
Atropine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic properties, so adding atropine can intensify dry mouth, constipation, urinary retention, tachycardia, confusion and heat intolerance. Anticholinergics may also reduce oral absorption of phenothiazines through slower gut motility.
What this interaction means in plain words
Atropine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Perphenazine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade, with possible reduced gastrointestinal absorption of oral perphenazine.
What to do
Monitor for anticholinergic toxicity and for loss of antipsychotic effect, particularly in elderly patients. Use the lowest atropine dose needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Perphenazine?
MediHelp rates the interaction as moderate. Atropine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has anticholinergic properties, so adding atropine can intensify dry mouth, constipation, urinary retention, tachycardia, confusion and heat intolerance. Anticholinergics may also reduce oral absorption of phenothiazines through slower gut motility.
How serious is the interaction between Atropine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and for loss of antipsychotic effect, particularly in elderly patients. Use the lowest atropine dose needed.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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