Drug interactions
Atropine iv / + Chlorpromazine
Severity: Moderate
Atropine iv / and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has anticholinergic effects that add to those of atropine, which can cause tachycardia, dry mouth, urinary retention, constipation, confusion, and hyperthermia. Reduced gut motility from atropine may also lower absorption of oral chlorpromazine.
What this interaction means in plain words
Atropine iv / and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with possible reduced chlorpromazine absorption from slowed GI transit.
What to do
Monitor for anticholinergic toxicity, especially in elderly patients and in hot environments. Watch for loss of antipsychotic effect if oral chlorpromazine is used repeatedly with atropine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Atropine iv / with Chlorpromazine?
MediHelp rates the interaction as moderate. Atropine iv / and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has anticholinergic effects that add to those of atropine, which can cause tachycardia, dry mouth, urinary retention, constipation, confusion, and hyperthermia. Reduced gut motility from atropine may also lower absorption of oral chlorpromazine.
How serious is the interaction between Atropine iv / and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in elderly patients and in hot environments. Watch for loss of antipsychotic effect if oral chlorpromazine is used repeatedly with atropine.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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