Drug interactions
Atropine iv / + Umeclidinium
Severity: Moderate
Atropine iv / and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic atropine adds antimuscarinic effects to inhaled umeclidinium. Tachycardia, dry mouth, urinary retention and constipation may be increased, though single clinical doses of atropine are usually tolerated.
What this interaction means in plain words
Atropine iv / and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor heart rate and for urinary retention when atropine is given, especially with repeated doses. Avoid long-term combination of systemic antimuscarinics with umeclidinium where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
- Dicyclomine + Umeclidinium Moderate
Frequently asked questions
Can I take Atropine iv / with Umeclidinium?
MediHelp rates the interaction as moderate. Atropine iv / and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic atropine adds antimuscarinic effects to inhaled umeclidinium. Tachycardia, dry mouth, urinary retention and constipation may be increased, though single clinical doses of atropine are usually tolerated.
How serious is the interaction between Atropine iv / and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and for urinary retention when atropine is given, especially with repeated doses. Avoid long-term combination of systemic antimuscarinics with umeclidinium where possible.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine. The full list is on the Umeclidinium page.
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