Drug interactions
Belladonna alkaloids + Umeclidinium
Severity: Moderate
Belladonna alkaloids and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids such as atropine, hyoscyamine and scopolamine are antimuscarinic and add to the effects of umeclidinium. This can cause dry mouth, constipation, urinary retention, tachycardia and confusion in older adults.
What this interaction means in plain words
Belladonna alkaloids and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use where an alternative exists. If needed, monitor for urinary retention, constipation and CNS effects, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
- Dicyclomine + Umeclidinium Moderate
Frequently asked questions
Can I take Belladonna alkaloids with Umeclidinium?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids such as atropine, hyoscyamine and scopolamine are antimuscarinic and add to the effects of umeclidinium. This can cause dry mouth, constipation, urinary retention, tachycardia and confusion in older adults.
How serious is the interaction between Belladonna alkaloids and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If needed, monitor for urinary retention, constipation and CNS effects, particularly in older patients.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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