Drug interactions
Dicyclomine + Umeclidinium
Severity: Moderate
Dicyclomine and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an antimuscarinic antispasmodic, so combining it with umeclidinium may increase anticholinergic adverse effects including dry mouth, constipation, urinary retention, blurred vision and tachycardia. Systemic umeclidinium exposure is low, but additive effects are possible in vulnerable patients.
What this interaction means in plain words
Dicyclomine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Umeclidinium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid unnecessary duplication of anticholinergic therapy, and monitor for urinary retention, constipation and eye symptoms, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Umeclidinium?
MediHelp rates the interaction as moderate. Dicyclomine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an antimuscarinic antispasmodic, so combining it with umeclidinium may increase anticholinergic adverse effects including dry mouth, constipation, urinary retention, blurred vision and tachycardia. Systemic umeclidinium exposure is low, but additive effects are possible in vulnerable patients.
How serious is the interaction between Dicyclomine and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of anticholinergic therapy, and monitor for urinary retention, constipation and eye symptoms, particularly in older patients.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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