Drug interactions
Atropine + Umeclidinium
Severity: Moderate
Atropine and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so using them together can increase anticholinergic effects such as dry mouth, tachycardia, urinary retention, constipation and blurred vision. The risk is greater with systemic atropine than with topical use.
What this interaction means in plain words
Atropine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Umeclidinium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid regular concurrent use of other anticholinergics where possible, and monitor heart rate, urinary function and eye symptoms if both are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
- Dicyclomine + Umeclidinium Moderate
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Umeclidinium?
MediHelp rates the interaction as moderate. Atropine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so using them together can increase anticholinergic effects such as dry mouth, tachycardia, urinary retention, constipation and blurred vision. The risk is greater with systemic atropine than with topical use.
How serious is the interaction between Atropine and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use of other anticholinergics where possible, and monitor heart rate, urinary function and eye symptoms if both are needed.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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