Drug interactions
Avanafil + Betaxolol
Severity: Moderate
Avanafil and Betaxolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil can add to the antihypertensive effect of beta-blockers such as betaxolol. Symptomatic hypotension is possible, though usually mild in stable patients.
What this interaction means in plain words
Avanafil and Betaxolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Betaxolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through PDE5-mediated vasodilation plus beta-blockade.
What to do
Begin avanafil at the lowest effective dose in patients on stable betaxolol. Monitor blood pressure and watch for orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Avanafil with Betaxolol?
MediHelp rates the interaction as moderate. Avanafil and Betaxolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil can add to the antihypertensive effect of beta-blockers such as betaxolol. Symptomatic hypotension is possible, though usually mild in stable patients.
How serious is the interaction between Avanafil and Betaxolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin avanafil at the lowest effective dose in patients on stable betaxolol. Monitor blood pressure and watch for orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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