Drug interactions
Avanafil + Butabarbital
Severity: Moderate
Avanafil and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital can induce hepatic and intestinal CYP3A4, lowering avanafil exposure. This may reduce the erectile response to avanafil.
What this interaction means in plain words
Avanafil and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases the metabolism of avanafil.
What to do
Assess erectile response; if efficacy is inadequate, consider an alternative therapy rather than exceeding the maximum labeled avanafil dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Butabarbital?
MediHelp rates the interaction as moderate. Avanafil and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital can induce hepatic and intestinal CYP3A4, lowering avanafil exposure. This may reduce the erectile response to avanafil.
How serious is the interaction between Avanafil and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess erectile response; if efficacy is inadequate, consider an alternative therapy rather than exceeding the maximum labeled avanafil dose.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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