Drug interactions
Avanafil + Carvedilol
Severity: Moderate
Avanafil and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol has alpha-blocking activity in addition to beta-blockade, so combining it with avanafil may cause additive hypotension. Orthostatic dizziness or syncope is possible, especially at initiation.
What this interaction means in plain words
Avanafil and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Carvedilol belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and the alpha- and beta-blocking activity of carvedilol.
What to do
Start avanafil at the lowest dose in patients on stable carvedilol. Monitor blood pressure and counsel on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Avanafil with Carvedilol?
MediHelp rates the interaction as moderate. Avanafil and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol has alpha-blocking activity in addition to beta-blockade, so combining it with avanafil may cause additive hypotension. Orthostatic dizziness or syncope is possible, especially at initiation.
How serious is the interaction between Avanafil and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose in patients on stable carvedilol. Monitor blood pressure and counsel on orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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