Drug interactions
Avanafil + Clonidine
Severity: Moderate
Avanafil and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine lowers blood pressure through central sympatholytic action, and avanafil adds vasodilation. The combination may cause additive hypotension and dizziness.
What this interaction means in plain words
Avanafil and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Clonidine belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism and PDE5-mediated vasodilation.
What to do
Start avanafil at a low dose in patients on stable clonidine. Monitor blood pressure and advise on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Avanafil with Clonidine?
MediHelp rates the interaction as moderate. Avanafil and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine lowers blood pressure through central sympatholytic action, and avanafil adds vasodilation. The combination may cause additive hypotension and dizziness.
How serious is the interaction between Avanafil and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at a low dose in patients on stable clonidine. Monitor blood pressure and advise on orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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