Drug interactions
Avanafil + Dabrafenib
Severity: Moderate
Avanafil and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower avanafil concentrations, reducing its clinical effect.
What this interaction means in plain words
Avanafil and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, accelerating avanafil metabolism.
What to do
Monitor for reduced erectile response and adjust the avanafil dose within labeled limits or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Avanafil with Dabrafenib?
MediHelp rates the interaction as moderate. Avanafil and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower avanafil concentrations, reducing its clinical effect.
How serious is the interaction between Avanafil and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced erectile response and adjust the avanafil dose within labeled limits or choose an alternative.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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