Drug interactions
Avanafil + Danazol
Severity: Minor
Avanafil and Danazol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may modestly raise avanafil concentrations, a sensitive CYP3A4 substrate. Adverse effects such as headache and hypotension may be slightly more likely.
What this interaction means in plain words
Avanafil and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4, reducing avanafil metabolism.
What to do
Start with the lowest avanafil dose and monitor blood pressure and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Danazol?
MediHelp rates the interaction as minor. Avanafil and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may modestly raise avanafil concentrations, a sensitive CYP3A4 substrate. Adverse effects such as headache and hypotension may be slightly more likely.
How serious is the interaction between Avanafil and Danazol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest avanafil dose and monitor blood pressure and tolerability.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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