Drug interactions
Avanafil + Diltiazem
Severity: Moderate
Avanafil and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor that reduces avanafil clearance and raises its exposure. Diltiazem also lowers blood pressure, so hypotension, flushing and headache may be more pronounced.
What this interaction means in plain words
Avanafil and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Diltiazem belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition by diltiazem decreasing avanafil metabolism, plus additive hypotensive effects.
What to do
Limit avanafil to 50 mg no more than once every 24 hours and monitor blood pressure and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Avanafil with Diltiazem?
MediHelp rates the interaction as moderate. Avanafil and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor that reduces avanafil clearance and raises its exposure. Diltiazem also lowers blood pressure, so hypotension, flushing and headache may be more pronounced.
How serious is the interaction between Avanafil and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to 50 mg no more than once every 24 hours and monitor blood pressure and tolerability.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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