Drug interactions
Avanafil + Enalapril
Severity: Moderate
Avanafil and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may potentiate the blood pressure lowering of ACE inhibitors. Dizziness or symptomatic hypotension can occur, particularly at initiation.
What this interaction means in plain words
Avanafil and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Enalapril belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and ACE inhibition.
What to do
Confirm blood pressure is controlled and start avanafil at a low dose. Monitor blood pressure and counsel on postural symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Avanafil with Enalapril?
MediHelp rates the interaction as moderate. Avanafil and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil may potentiate the blood pressure lowering of ACE inhibitors. Dizziness or symptomatic hypotension can occur, particularly at initiation.
How serious is the interaction between Avanafil and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm blood pressure is controlled and start avanafil at a low dose. Monitor blood pressure and counsel on postural symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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