Drug interactions
Avanafil + Encorafenib
Severity: Moderate
Avanafil and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so avanafil exposure may rise or fall unpredictably. This could cause either more adverse effects or loss of efficacy.
What this interaction means in plain words
Avanafil and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Encorafenib belongs to Oncology.
Why it happens
Encorafenib both inhibits and induces CYP3A4, altering avanafil metabolism.
What to do
Monitor the erectile response and tolerability, and adjust avanafil use accordingly, staying within the labeled maximum dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Avanafil with Encorafenib?
MediHelp rates the interaction as moderate. Avanafil and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed inhibitory and inducing effects on CYP3A4, so avanafil exposure may rise or fall unpredictably. This could cause either more adverse effects or loss of efficacy.
How serious is the interaction between Avanafil and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the erectile response and tolerability, and adjust avanafil use accordingly, staying within the labeled maximum dose.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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