Drug interactions
Avanafil + Fexinidazole
Severity: Moderate
Avanafil and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase avanafil concentrations. This may enhance hypotension, visual effects and priapism.
What this interaction means in plain words
Avanafil and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing avanafil metabolism.
What to do
Defer avanafil during the short fexinidazole course if possible; otherwise use the lowest dose and monitor blood pressure and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Fexinidazole?
MediHelp rates the interaction as moderate. Avanafil and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase avanafil concentrations. This may enhance hypotension, visual effects and priapism.
How serious is the interaction between Avanafil and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer avanafil during the short fexinidazole course if possible; otherwise use the lowest dose and monitor blood pressure and adverse effects.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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