Drug interactions
Avanafil + Hydrochlorothiazide-olmesartan
Severity: Moderate
Avanafil and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a vasodilating PDE5 inhibitor, and combined with antihypertensives it can produce additive blood pressure lowering with symptomatic hypotension. The risk is greatest in volume-depleted patients or those on multiple antihypertensives.
What this interaction means in plain words
Avanafil and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and antihypertensive drug effects.
What to do
Start avanafil at the lowest dose and counsel patients about orthostatic symptoms. Ensure blood pressure is stable and the patient is not volume depleted before use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Avanafil and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a vasodilating PDE5 inhibitor, and combined with antihypertensives it can produce additive blood pressure lowering with symptomatic hypotension. The risk is greatest in volume-depleted patients or those on multiple antihypertensives.
How serious is the interaction between Avanafil and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose and counsel patients about orthostatic symptoms. Ensure blood pressure is stable and the patient is not volume depleted before use.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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