Drug interactions
Avanafil + Indapamide
Severity: Moderate
Avanafil and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide has diuretic and vasodilating properties that lower blood pressure, and avanafil can add to this effect. Dizziness and symptomatic hypotension may result.
What this interaction means in plain words
Avanafil and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Indapamide belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects (pharmacodynamic synergism).
What to do
Ensure blood pressure is stable and the patient is not volume depleted before starting avanafil. Monitor for orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Avanafil with Indapamide?
MediHelp rates the interaction as moderate. Avanafil and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide has diuretic and vasodilating properties that lower blood pressure, and avanafil can add to this effect. Dizziness and symptomatic hypotension may result.
How serious is the interaction between Avanafil and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure blood pressure is stable and the patient is not volume depleted before starting avanafil. Monitor for orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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