Drug interactions
Avanafil + Nitroglycerin po
Severity: Contraindicated
Avanafil and Nitroglycerin po: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil potentiates the hypotensive action of oral nitroglycerin. Severe hypotension, syncope and myocardial ischemia may result.
What this interaction means in plain words
Avanafil and Nitroglycerin po are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nitric oxide donation increases cGMP and avanafil inhibits PDE5, producing additive vasodilation.
What to do
Do not combine; avoid nitrates for at least 12 hours after avanafil per labeling. Use non-nitrate antianginal therapy if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Nitroglycerin po?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroglycerin po are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Avanafil potentiates the hypotensive action of oral nitroglycerin. Severe hypotension, syncope and myocardial ischemia may result.
How serious is the interaction between Avanafil and Nitroglycerin po?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid nitrates for at least 12 hours after avanafil per labeling. Use non-nitrate antianginal therapy if needed.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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