Drug interactions
Avanafil + Nitroglycerin rectal
Severity: Contraindicated
Avanafil and Nitroglycerin rectal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal nitroglycerin given with avanafil can cause an exaggerated drop in blood pressure. This may lead to syncope or cardiac ischemia.
What this interaction means in plain words
Avanafil and Nitroglycerin rectal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cGMP-mediated vasodilation from nitrate-derived nitric oxide and PDE5 inhibition.
What to do
Avoid the combination; keep nitrates away from avanafil dosing by at least the labeled interval (12 hours). Consider alternative therapy for the nitrate indication.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avanafil and Nitroglycerin rectal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Nitroglycerin rectal?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroglycerin rectal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rectal nitroglycerin given with avanafil can cause an exaggerated drop in blood pressure. This may lead to syncope or cardiac ischemia.
How serious is the interaction between Avanafil and Nitroglycerin rectal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; keep nitrates away from avanafil dosing by at least the labeled interval (12 hours). Consider alternative therapy for the nitrate indication.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
