Drug interactions
Avanafil + Nitroglycerin transdermal
Severity: Contraindicated
Avanafil and Nitroglycerin transdermal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Continuous nitroglycerin from patches plus avanafil can cause sustained excessive vasodilation and hypotension. Syncope and ischemic events are possible.
What this interaction means in plain words
Avanafil and Nitroglycerin transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive increase in cGMP from nitric oxide donation and PDE5 inhibition.
What to do
Avoid avanafil in patients using nitrate patches. Choose a non-nitrate antianginal if avanafil is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Nitroglycerin transdermal?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroglycerin transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Continuous nitroglycerin from patches plus avanafil can cause sustained excessive vasodilation and hypotension. Syncope and ischemic events are possible.
How serious is the interaction between Avanafil and Nitroglycerin transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid avanafil in patients using nitrate patches. Choose a non-nitrate antianginal if avanafil is needed.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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