Drug interactions
Avanafil + Nitroglycerin translingual
Severity: Contraindicated
Avanafil and Nitroglycerin translingual: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Translingual nitroglycerin used after avanafil may cause a precipitous fall in blood pressure. This can cause syncope or cardiac ischemia.
What this interaction means in plain words
Avanafil and Nitroglycerin translingual are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nitric oxide donation and PDE5 inhibition both increase cGMP, resulting in additive vasodilation.
What to do
Do not use within 12 hours of avanafil. Instruct patients to seek emergency care for angina and report recent avanafil use.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Nitroglycerin translingual?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroglycerin translingual are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Translingual nitroglycerin used after avanafil may cause a precipitous fall in blood pressure. This can cause syncope or cardiac ischemia.
How serious is the interaction between Avanafil and Nitroglycerin translingual?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 12 hours of avanafil. Instruct patients to seek emergency care for angina and report recent avanafil use.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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