Drug interactions
Avanafil + Nitroprusside
Severity: Contraindicated
Avanafil and Nitroprusside: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside releases nitric oxide and, with avanafil, can cause excessive hypotension. PDE5 inhibitors potentiate nitric oxide donors, and severe blood pressure drops are expected.
What this interaction means in plain words
Avanafil and Nitroprusside are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nitroprusside-derived nitric oxide increases cGMP and avanafil prevents its degradation via PDE5 inhibition, producing additive vasodilation.
What to do
Avoid using nitroprusside in patients who recently took avanafil. If unavoidable, use with continuous arterial blood pressure monitoring and careful titration.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Nitroprusside?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroprusside are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nitroprusside releases nitric oxide and, with avanafil, can cause excessive hypotension. PDE5 inhibitors potentiate nitric oxide donors, and severe blood pressure drops are expected.
How serious is the interaction between Avanafil and Nitroprusside?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using nitroprusside in patients who recently took avanafil. If unavoidable, use with continuous arterial blood pressure monitoring and careful titration.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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