Drug interactions
Avanafil + Penbutolol
Severity: Moderate
Avanafil and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol lowers blood pressure and avanafil adds vasodilation, so the combination may cause symptomatic hypotension. The effect is usually modest in stable patients.
What this interaction means in plain words
Avanafil and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from beta-blockade and PDE5 inhibitor vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms, and ensure the patient is hemodynamically stable before starting avanafil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Penbutolol?
MediHelp rates the interaction as moderate. Avanafil and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penbutolol lowers blood pressure and avanafil adds vasodilation, so the combination may cause symptomatic hypotension. The effect is usually modest in stable patients.
How serious is the interaction between Avanafil and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and ensure the patient is hemodynamically stable before starting avanafil.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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