Drug interactions
Avanafil + Quinapril
Severity: Moderate
Avanafil and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil has vasodilating effects that add to the antihypertensive action of quinapril. Patients may experience lowered blood pressure with dizziness or lightheadedness.
What this interaction means in plain words
Avanafil and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering through PDE5 inhibition and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting avanafil. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Quinapril?
MediHelp rates the interaction as moderate. Avanafil and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil has vasodilating effects that add to the antihypertensive action of quinapril. Patients may experience lowered blood pressure with dizziness or lightheadedness.
How serious is the interaction between Avanafil and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting avanafil. Counsel patients to rise slowly.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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