Drug interactions
Avanafil + Telmisartan-amlodipine
Severity: Moderate
Avanafil and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a vasodilator and can add to the blood pressure lowering effect of amlodipine and telmisartan, leading to symptomatic hypotension. Amlodipine is a weak CYP3A4 inhibitor and may marginally raise avanafil levels.
What this interaction means in plain words
Avanafil and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive vasodilation through PDE5 inhibition with calcium channel and angiotensin receptor blockade.
What to do
Start avanafil at a low dose and counsel on postural hypotension symptoms. Monitor blood pressure after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Avanafil and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a vasodilator and can add to the blood pressure lowering effect of amlodipine and telmisartan, leading to symptomatic hypotension. Amlodipine is a weak CYP3A4 inhibitor and may marginally raise avanafil levels.
How serious is the interaction between Avanafil and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at a low dose and counsel on postural hypotension symptoms. Monitor blood pressure after initiation.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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