Drug interactions
Avapritinib + Azelastine-fluticasone
Severity: Minor
Avapritinib and Azelastine-fluticasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is reported to inhibit CYP3A4 only weakly, and avapritinib is a CYP3A4 substrate. A clinically meaningful rise in avapritinib exposure from the nasal azelastine-fluticasone product is unlikely, and the interaction is largely theoretical.
What this interaction means in plain words
Avapritinib and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by azelastine, with low systemic exposure after intranasal use.
What to do
No dose change is needed. Monitor for avapritinib adverse effects such as cognitive effects and edema as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Azelastine-fluticasone?
MediHelp rates the interaction as minor. Avapritinib and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine is reported to inhibit CYP3A4 only weakly, and avapritinib is a CYP3A4 substrate. A clinically meaningful rise in avapritinib exposure from the nasal azelastine-fluticasone product is unlikely, and the interaction is largely theoretical.
How serious is the interaction between Avapritinib and Azelastine-fluticasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for avapritinib adverse effects such as cognitive effects and edema as part of routine care.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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