Drug interactions
Avapritinib + Baclofen
Severity: Moderate
Avapritinib and Baclofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence, which may be compounded by baclofen's sedative action.
What this interaction means in plain words
Avapritinib and Baclofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Baclofen belongs to Musculoskeletal.
Why it happens
Additive CNS adverse effects; avapritinib neurocognitive toxicity mechanism is not fully established.
What to do
Monitor cognition and alertness, and reduce the baclofen dose if oversedation or confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Baclofen?
MediHelp rates the interaction as moderate. Avapritinib and Baclofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence, which may be compounded by baclofen's sedative action.
How serious is the interaction between Avapritinib and Baclofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and alertness, and reduce the baclofen dose if oversedation or confusion develops.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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