Drug interactions
Avapritinib + Brompheniramine
Severity: Moderate
Avapritinib and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which brompheniramine may worsen. The result is increased impairment of alertness and memory.
What this interaction means in plain words
Avapritinib and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Brompheniramine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for cognitive impairment and sedation, and use a non-sedating antihistamine if one is needed. Manage avapritinib dosing per labeling if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Brompheniramine?
MediHelp rates the interaction as moderate. Avapritinib and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which brompheniramine may worsen. The result is increased impairment of alertness and memory.
How serious is the interaction between Avapritinib and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive impairment and sedation, and use a non-sedating antihistamine if one is needed. Manage avapritinib dosing per labeling if effects occur.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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