Drug interactions
Avapritinib + Cariprazine
Severity: Moderate
Avapritinib and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib commonly causes cognitive effects, dizziness and fatigue, which can add to the sedation produced by cariprazine. Combined use may impair alertness and concentration.
What this interaction means in plain words
Avapritinib and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Cariprazine belongs to Central Nervous System.
Why it happens
Additive CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor for worsening cognitive impairment or sedation and counsel on driving. Reduce or interrupt avapritinib per labeling if cognitive adverse effects become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Cariprazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Cariprazine?
MediHelp rates the interaction as moderate. Avapritinib and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib commonly causes cognitive effects, dizziness and fatigue, which can add to the sedation produced by cariprazine. Combined use may impair alertness and concentration.
How serious is the interaction between Avapritinib and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening cognitive impairment or sedation and counsel on driving. Reduce or interrupt avapritinib per labeling if cognitive adverse effects become significant.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
