Drug interactions
Avapritinib + Cimetidine
Severity: Moderate
Avapritinib and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and cimetidine may modestly increase its exposure. Higher avapritinib levels raise the risk of cognitive effects, intracranial bleeding and edema. The effect of a weak inhibitor is likely small.
What this interaction means in plain words
Avapritinib and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine weakly inhibits CYP3A4, reducing avapritinib clearance.
What to do
Consider an H2 antagonist with less CYP inhibition, such as famotidine, and monitor for cognitive changes and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Cimetidine?
MediHelp rates the interaction as moderate. Avapritinib and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib is a CYP3A4 substrate, and cimetidine may modestly increase its exposure. Higher avapritinib levels raise the risk of cognitive effects, intracranial bleeding and edema. The effect of a weak inhibitor is likely small.
How serious is the interaction between Avapritinib and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an H2 antagonist with less CYP inhibition, such as famotidine, and monitor for cognitive changes and bleeding.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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