Drug interactions
Avapritinib + Ciprofloxacin
Severity: Moderate
Avapritinib and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin may raise avapritinib concentrations through CYP3A4 inhibition, increasing the risk of cognitive effects, bleeding and other toxicities. Avapritinib labeling advises avoiding strong and moderate CYP3A4 inhibitors.
What this interaction means in plain words
Avapritinib and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated avapritinib metabolism.
What to do
Prefer a non-CYP3A4-inhibiting antibiotic. If unavoidable, monitor for cognitive effects and bleeding and consider avapritinib dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ciprofloxacin?
MediHelp rates the interaction as moderate. Avapritinib and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ciprofloxacin may raise avapritinib concentrations through CYP3A4 inhibition, increasing the risk of cognitive effects, bleeding and other toxicities. Avapritinib labeling advises avoiding strong and moderate CYP3A4 inhibitors.
How serious is the interaction between Avapritinib and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting antibiotic. If unavoidable, monitor for cognitive effects and bleeding and consider avapritinib dose reduction.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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