Drug interactions
Avapritinib + Doxycycline
Severity: Minor
Avapritinib and Doxycycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxycycline is at most a weak CYP3A4 inhibitor, so any rise in avapritinib exposure is probably small. The label advice about moderate CYP3A4 inhibitors is aimed at agents with stronger inhibition, and the effect of doxycycline on avapritinib has not been well characterised.
What this interaction means in plain words
Avapritinib and Doxycycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Doxycycline belongs to Anti Bacterial.
Why it happens
Possible weak inhibition of CYP3A4-mediated avapritinib metabolism, which is not firmly established for doxycycline.
What to do
No dose change is generally needed; monitor for avapritinib adverse effects such as cognitive effects, edema and bleeding. If a clear moderate CYP3A4 inhibitor is needed, follow the avapritinib labeled dose reduction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Doxycycline?
MediHelp rates the interaction as minor. Avapritinib and Doxycycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxycycline is at most a weak CYP3A4 inhibitor, so any rise in avapritinib exposure is probably small. The label advice about moderate CYP3A4 inhibitors is aimed at agents with stronger inhibition, and the effect of doxycycline on avapritinib has not been well characterised.
How serious is the interaction between Avapritinib and Doxycycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for avapritinib adverse effects such as cognitive effects, edema and bleeding. If a clear moderate CYP3A4 inhibitor is needed, follow the avapritinib labeled dose reduction.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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