Drug interactions
Avapritinib + Eszopiclone
Severity: Moderate
Avapritinib and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects, dizziness and somnolence, and eszopiclone adds sedation and complex sleep behaviors. The combination may increase cognitive and psychomotor impairment.
What this interaction means in plain words
Avapritinib and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Eszopiclone belongs to Central Nervous System.
Why it happens
Additive CNS effects; avapritinib neurocognitive adverse effects with GABA-A mediated sedation from eszopiclone.
What to do
Monitor for confusion, memory impairment and excessive sedation. Reduce or stop eszopiclone if cognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Eszopiclone?
MediHelp rates the interaction as moderate. Avapritinib and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects, dizziness and somnolence, and eszopiclone adds sedation and complex sleep behaviors. The combination may increase cognitive and psychomotor impairment.
How serious is the interaction between Avapritinib and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, memory impairment and excessive sedation. Reduce or stop eszopiclone if cognitive effects emerge.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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