Drug interactions
Avapritinib + Hydrocodone
Severity: Moderate
Avapritinib and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may be compounded by the sedative effects of hydrocodone. The result may be more impaired alertness and greater CNS depression.
What this interaction means in plain words
Avapritinib and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive CNS effects; avapritinib neurocognitive toxicity combined with opioid-induced sedation.
What to do
Monitor for drowsiness, confusion and cognitive changes, and use the lowest effective hydrocodone dose. Counsel patients about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Hydrocodone?
MediHelp rates the interaction as moderate. Avapritinib and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may be compounded by the sedative effects of hydrocodone. The result may be more impaired alertness and greater CNS depression.
How serious is the interaction between Avapritinib and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, confusion and cognitive changes, and use the lowest effective hydrocodone dose. Counsel patients about driving and machinery.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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