Drug interactions
Avapritinib + Lapatinib
Severity: Moderate
Avapritinib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a weak-to-moderate CYP3A4 inhibitor and may increase avapritinib exposure. This may worsen avapritinib toxicities such as cognitive effects, bleeding and edema.
What this interaction means in plain words
Avapritinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of avapritinib by lapatinib.
What to do
Avoid if possible. If unavoidable, reduce the avapritinib dose per labeling and monitor for neurocognitive effects and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Lapatinib?
MediHelp rates the interaction as moderate. Avapritinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a weak-to-moderate CYP3A4 inhibitor and may increase avapritinib exposure. This may worsen avapritinib toxicities such as cognitive effects, bleeding and edema.
How serious is the interaction between Avapritinib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the avapritinib dose per labeling and monitor for neurocognitive effects and bleeding.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
